Unfortunately, Columbus and the Spaniards were not unique. They conquered Mexico and what is now the Southwestern U.S., with forays into Florida, the Carolinas, even into Virginia. From Virginia northward, the land had been taken by the English who, if anything, had even less tolerance for the indigenous people.
As Hans Koning says,
“From the beginning, the Spaniards saw the native Americans as natural slaves, beasts of burden, part of the loot. When working them to death was more economical than treating them somewhat humanely, they worked them to death.
“The English, on the other hand, had no use for the native peoples. They saw them as devil worshippers, savages who were beyond salvation by the church, and exterminating them increasingly became accepted policy.”

The British arrived in Jamestown in 1607. By 1610 the intentional extermination of the native population was well along. As David E. Stannard has written,
“Hundreds of Indians were killed in skirmish after skirmish. Other hundreds were killed in successful plots of mass poisoning. They were hunted down by dogs, ‘blood-Hounds to draw after them, and Mastives [mastiffs] to seize them.’
“Their canoes and fishing weirs were smashed, their villages and agricultural fields burned to the ground. Indian peace offers were accepted by the English only until their prisoners were returned; then, having lulled the natives into false security, the colonists returned to the attack.
“It was the colonists’ expressed desire that the Indians be exterminated, rooted ‘out from being longer a people upon the face of the Earth.’ In a single raid the settlers destroyed corn sufficient to feed four thousand people for a year.
“Starvation and the massacre of non-combatants was becoming the preferred British approach to dealing with the natives.”